Re: [IAC#RG] New DRDO Drug 2-DG is based on Acharya Balkrishna’s research

Dear all, 

Thanks to Dr Rajan for his reply. There is lot of research on 2-DG use in cancer treatment. Considering the fact that there is no proven and 100% effective drug against COVID, research community is testing the efficacy of various antiviral n other drugs to treat COVID (repurposed drug). Kudos to DRDO and let us hope that the drug is successful. 

Dr Swati Kotwal (Retd)

University Department of Biochemistry RTMNU Nagpur

Sent from my iPhone

On 14-May-2021, at 8:17 PM, m.g.r. rajan <mgr_rajan@hotmail.com> wrote:



I too searched literature on 2-DG and found this pre-print (meaning not peer-reviewed) publication from Patanjali on Researchgate website. It is a theoretical study based on computer simulation. One of the co-authors is an ex-Director of a DRDO-Institute. 

2-DG is a long-known molecule, having been developed as an anti-cancer metabolite. The present group has boldly tested it in Covid-19 patients and have shown favourable results and have obtained DCGI-approval. To that extent the work done is novel. It remains to be seen how it works out in field use. The side effects 

Incidentally, DRDO-INMAS has published papers using this molecule more than a decade ago as an adjuvant in radiation therapy for a few cancers. 

However, some experts have expressed reservations against 2-DG for treating covid-19 patients as expressed in The Hindu. 

There is a Swedish company that announced on March 11th, a nasal spray containing 2-DG.

Dr. Rajan

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From: indiaresists-request@lists.riseup.net <indiaresists-request@lists.riseup.net> on behalf of Pankaj Jangid <pankaj@codeisgreat.org>
Sent: Friday, May 14, 2021 10:25 AM
To: indiaresists@lists.riseup.net <indiaresists@lists.riseup.net>
Subject: [IAC#RG] New DRDO Drug 2-DG is based on Acharya Balkrishna's research

 

I started to dig about this new drug 2-DG, which was launched last week
by DRDO and Dr. Reddy's. This drug is claimed to reduce the oxygen
demand by a body infected with covid-19.

Reading more on this, I found that this is actually based on a research
paper by Acharya Balkrishna et al. of Patanjali Ayurveda. Here is the
original paper published on the aggregator ResearchGate:

https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.researchgate.net%2Fpublication%2F340332773_Glucose_antimetabolite_2-Deoxy-D-Glucose_and_its_derivative_as_promising_candidates_for_tackling_COVID-19_Insights_derived_from_in_silico_docking_and_molecular_simulations&amp;data=04%7C01%7C%7Caac01eb4e3cf44a4a7fc08d916bb719d%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637565816615923917%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&amp;sdata=a8ahOYlOxOBv6QoAL4ICihR09l%2Fa2tDD%2FMf82uU95SE%3D&amp;reserved=0

--
Regards,
Pankaj Jangid

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